Guanidine hydrochloride 50-01-1 can inhibit the growth of cancer cells

Guanidine hydrochloride, also known as amidine hydrochloride, CAS: 50-01-1, is a widely used biological reagent and one of the advantageous products of subfamily. Guanidine hydrochloride 50-01-1 can be used as medicine, pesticide, dye and other organic synthetic intermediates. It is also an important raw material for the manufacture of sulfadiazine, sulfamethylpyrimidine, sulfamethazine and other drugs and folic acid. It can also be used as an antistatic agent for synthetic fibers.

It is worth mentioning that guanidine hydrochloride is a strong denaturant in the experiment of extracting cell total nucleic acid and plays an important role in nucleic acid detection. Guanidine hydrochloride solution can dissolve proteins, resulting in the destruction of cell structure and the secondary structure of nucleoprotein, which can be dissociated from nucleic acid. In addition, nuclease can be inactivated by reducing agents such as guanidine hydrochloride.

In addition, according to published reports, guanidine hydrochloride has an inhibitory effect on the growth of cancer cells and plays a role in the treatment and prevention of cancer.

Cancer cells are the source of cancer. They are derived from normal cells. The process of ingestion of nutrients is different from normal cells. For example, hepatoma cells and breast cancer cells can absorb large nucleic acids, which are also related to their function of drinking, but normal organs such as hepatocytes do not have this function. Cancer cells proliferate through rapid uptake of nutrients. If they can inhibit the uptake of cancer cells, they can inhibit the growth of cancer cells.

Guanidine hydrochloride can destroy or interfere with the hydrogen bond between polar molecules on the surface of cancer cells and macromolecules, and then inhibit the rapid uptake of cancer cells. The results showed that guanidine hydrochloride (10-35mg / kg • day) had a significant effect on inhibiting the uptake of DNA by cancer cells, and then could effectively inhibit the proliferation of cancer cells; At the same time, the inhibition rate of guanidine hydrochloride on liver cancer can reach 42% after 9 days of injection; After 7 days of injection of guanidine hydrochloride, the tumor inhibition rate of lung cancer can reach 56.8%.

The experimental results show that guanidine hydrochloride can significantly inhibit the cancer cells of animals with cancer / tumor, and has obvious technical effect. This discovery has a far-reaching impact on the use of guanidine hydrochloride as a cancer cell growth inhibitor, and enables the invention to determine new therapeutic applications, especially in the field of cancer treatment.