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What is guanidine thiocyanate and what is it used for?


Guanidine hydrochloride is a powerful chaotropic agent. Not only does it facilitate the solubility of hydrophobic molecules, it can also be used for protein denaturation and subsequent denaturation. In high concentrations of guanidine hydrochloride solution, the ordered "secondary structure" of all proteins (maintained by intermolecular non-covalent interactions such as hydrogen and hydrophobic bonds) is disrupted, peptide chains are extended, and tertiary structures are disrupted . Change. 

Guanidine hydrochloride can dissolve insoluble or denatured proteins, such as inclusion bodies, and recover periplasmic proteins. It can also be used in the first steps of protein development or enzymatic folding, which may require urea and DTT. Guanidine hydrochloride is also commonly used in RNA purification to dissociate nuclear proteins and inhibit RNase activity. Guanidine hydrochloride is mainly used as an intermediate in pharmaceuticals, pesticides, dyes and other organic synthesis. 

Guanidine hydrochloride is an important raw material for the production of sulfadiazine, sulfamethazine, sulfamethazine and folic acid. It can also be used as an antistatic agent for synthetic fibers. In addition, guanidine hydrochloride can also be used as a detection reagent for the detection of gold , iridium, os, platinum, ruthenium and other precious metals. Advantages of monoguanidine (polyhexamethyleneguanidine hydrochloride, PHMG), biguanide (polyhexamethylene biguanide hydrochloride, PHMB), guanidine thiocyanate, guanidine hydrochloride, guanidine carbonate, interested can log on www.tzchemicals.com contact us.