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What are the effects of guanidine hydrochloride?
2023-04-10
1. It can be used as an intermediate in medicine, pesticides, dyes, and other organic synthesis. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine, and is an intermediate in the production of sulfonamide drugs such as sulfadiazine, sulfamethylpyrimidine, and sulfamethoxypyrimidine.
2. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to form 2,4-diamino-6-hydroxypyrimidine, which is used to synthesize the anti anemia drug folic acid. It can also be used as an anti-static agent for synthetic fibers.
3. It can also be used as a protein denaturant.
4. As a strong denaturant in the experiment of extracting total RNA from cells. Guanidine hydrochloride solution can dissolve proteins, causing damage to cell structure, secondary structure of nuclear proteins, and dissociation from nucleic acids. In addition, RNA enzymes can be inactivated by reducing agents such as guanidine hydrochloride.
2. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to form 2,4-diamino-6-hydroxypyrimidine, which is used to synthesize the anti anemia drug folic acid. It can also be used as an anti-static agent for synthetic fibers.
3. It can also be used as a protein denaturant.
4. As a strong denaturant in the experiment of extracting total RNA from cells. Guanidine hydrochloride solution can dissolve proteins, causing damage to cell structure, secondary structure of nuclear proteins, and dissociation from nucleic acids. In addition, RNA enzymes can be inactivated by reducing agents such as guanidine hydrochloride.
