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What are the uses of guanidine hydrochloride?

2022-04-19

Guanidine hydrochloride is an organic substance with a chemical formula of CH6ClN3 in the form of white or pale yellow lumps. It is used as an intermediate of organic compounds such as medicine, pesticide, dye and so on. It is an important raw material for the manufacture of sulfonamides and folic acid. It can also be used as an antistatic agent for synthetic fibers.

Guanidine hydrochloride is unstable and can be hydrolyzed in aqueous solution to generate ammonia and urea, so its toxicity is the same as urea, while the toxicity of guanidine and its derivatives is generally higher than that of urea.

Use of guanidine hydrochloride

1. Guanidine hydrochloride can be used as an intermediate in organic synthesis such as medicines, pesticides and dyes. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine, and manufacture sulfadiazine, sulfamethazine, sulfamethazine and other sulfa drugs. middle.

2. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to generate 2,4-diamino-6-hydroxypyrimidine, which is used to synthesize the anti-anemia drug folic acid. It can also be used as an antistatic agent for synthetic fibers.

3. Guanidine hydrochloride can also be used as a protein denaturant.

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